Human Anti-SLC30A8 Recombinant Antibody (clone C22)
CAT#: HPAB-0040-CN
A monoclonal antibody specifically binds to ZnT8 which can be used for diagnosing and treating type-1 diabetes mellitus and preparing prognosis reagents.
Gene Expression
Tested Data
Normal Tissue
Figure 1 High expression in pancreas
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/76165/166123_A_1_3_selected.jpg
Normal Tissue
Figure 2 Low expression in liver
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/76165/166123_A_9_4_val_selected.jpg
Normal Tissue
Figure 3 Pancreas
Pancreatic endocrine cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/76165/166123_A_2_3.jpg
RNA Expression
Figure 4 RNA cell line category: Group enriched (U-266/70, U-266/84)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000164756-SLC30A8
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SEC-HPLC
Figure 1 Human Anti-SLC30A8 Recombinant Antibody (clone C22) (HPAB-0040-CN) in HPLC
The purity of HPAB-0040-CN was 99.74% as determined by SEC-HPLC.
SDS-PAGE
Figure 2 Human Anti-SLC30A8 Recombinant Antibody (clone C22) (HPAB-0040-CN) in SDS-PAGE
SDS-PAGE analysis of HPAB-0040-CN in β-mercaptoethanol-reduced (Lane 2) and non-reduced (Lane 1) conditions. Gel stained for 30 minutes with Coomassie Blue. As a result of different β-mercaptoethanol-reduced proteins (Heavy chain and Light chain) migrate as about 50 kDa and 25 kDa, respectively. And non-reduced protein migrates as about 180 kDa.
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Specifications
- Immunogen
- Purified fusion proteins of ZnT8
- Host Species
- Human
- Derivation
- Phage display library
- Type
- Human IgG
- Specificity
- Human SLC30A8
- Species Reactivity
- Human
- Clone
- C22
- Applications
- ELISA, WB, IHC
- Related Disease
- Type-1 diabetes mellitus
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
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Reliable for Long-term Studies
This antibody's consistency across different batches has been critical for our long-term studies. Its high reproducibility ensures the reliability of our findings related to SLC30A8's role in pancreatic functions, making it an invaluable tool in our research.
Supports Therapeutic Development
Our development of therapeutic strategies targeting β-cell dysfunction has been supported significantly by this antibody. It allows us to pinpoint how modifications in zinc transport can enhance insulin secretion, informing our therapeutic research directions.
Great Addition to Diabetes Biomarker Research
This antibody has been a great asset in our research on diabetes biomarkers. It facilitates the detection and analysis of SLC30A8, providing valuable information that supports the identification of potential metabolic targets and interventions.
Q&As
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How is this antibody used to study genetic variations associated with diabetes?
A: The antibody helps evaluate how genetic variations in SLC30A8 influence its expression and function, which can correlate with diabetes risk. Such studies contribute to understanding the genetic predisposition to diabetes and identifying potential targets for intervention.
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What insights does this antibody provide into therapeutic strategies for diabetes?
A: By elucidating the role of SLC30A8 in zinc transport and insulin regulation, this antibody provides insights into potential therapeutic strategies that aim to enhance β-cell function or zinc homeostasis, offering promising avenues for diabetes management and treatment.
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What is the primary application of the Human Anti-SLC30A8 Recombinant Antibody (Clone C22) in research?
A: This recombinant antibody is mainly used to study SLC30A8, a zinc transporter protein, in the context of diabetes research. It is instrumental in immunohistochemistry, Western blotting, and ELISA to explore the role of zinc homeostasis in pancreatic islet function and glucose metabolism, aiding in the understanding of diabetes pathogenesis.
View the frequently asked questions answered by Creative Biolabs Support.
Cite This Product
To accurately reference this product in your publication, please use the following citation information:
(Creative Biolabs Cat# HPAB-0040-CN, RRID: AB_3111350)
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Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
See other products for "Clone C22"
- CAT
- Product Name
See other products for "SLC30A8"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1748z | Mouse Anti-SLC30A8 Recombinant Antibody (clone 29C9) | ELISA, WB, IF, FuncS | Mouse IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0040-CN-S(P) | Human Anti-SLC30A8 Recombinant Antibody (clone C22); scFv Fragment | ELISA, WB, IHC | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0040-CN-F(E) | Human Anti-SLC30A8 Recombinant Antibody (clone C22); Fab Fragment | ELISA, WB, IHC | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN1215 | FITC-A*02:01/Human SLC30A8 (FLLSLFSLWL) MHC Tetramer | FCM, IHC | |
| MHC-CN1216 | A*02:01/Human SLC30A8 (FLLSLFSLWL) MHC Tetramer | FCM, IHC | |
| MHC-CN1217 | PE-A*02:01/Human SLC30A8 (HIAGSLAVV) MHC Tetramer | FCM, IHC | |
| MHC-CN1218 | APC-A*02:01/Human SLC30A8 (HIAGSLAVV) MHC Tetramer | FCM, IHC | |
| MHC-CN1219 | FITC-A*02:01/Human SLC30A8 (HIAGSLAVV) MHC Tetramer | FCM, IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC663 | Recombinant Anti-SLC30A8 Vesicular Antibody, EV Displayed (VS-0425-YC663) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY6671 | Anti-SLC30A8 Immunohistochemistry Kit | IHC |
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